The product is intended for subcutaneous (s / c) and intravenous (i / v) administration. The initial dose is 50 mg / d n / k1 or 2 times per day. Thereafter, the number of injections and dosage may be gradually increased starting from tolerability, clinical deca durabolin cycle response and the effects on andriol dosage the levels of hormones produced by the tumor (for carcinoid tumors -vozdeystvie on urinary excretion of 5-hydroxyindole acetic acid).The drug is typically used 2-3 times per day.
Acromegaly drug is administered subcutaneously in an initial dose of 50-100 ug at intervals of 8 or 12 hours. In further dose selection is based on the monthly definitions growth hormone concentration in blood, analysis of clinical symptoms and tolerability. The majority of patients a daily dosage of 200-300 micrograms. Do not exceed the maximum dose of 1500 mg / day. If after three months. treatment is not marked enough decline of growth hormone and improving the clinical picture of the disease, therapy should be discontinued.
In endocrine tumors gastroenteritis-pancreatic system – preparatat injected s / c at an initial dose of 50 mg 1-2 times a day. Further, depending on the achieved effect and influence on the concentration of hormones produced by the tumor (for carcinoid tumors – influence the selection of 5-hydroxyindoleacetic acid excretion), and tolerability, the dose can be gradually increased to 100-200 mg 3 times a day.
For the prevention of complications after surgery on the pancreas – n / a, the first dose of 100 mg for 1 h prior to laparotomy after surgery – 100 mg 3 times a day for 7 consecutive days. In exceptional cases, may require higher doses. Supporting dose should be adjusted individually. If therapy is in the maximum tolerated dose is not effective for 1 week, therapy should be discontinued.
To stop bleeding deca durabolin cycle from varicose veins of the esophagus – / drip at a rate of 25 g / h for 5 days.
When s / c administration to avoid multiple injections of the drug in the same place within a short period of time. The on / in the introduction of the drug prior to use contents of the vial for single use or reusable bottle to be diluted in saline. The amount of dilution will depend on the infusion system used and should be modified to provide continuous administration of octreotide with the recommended rate.After the drug was dissolved, the resulting solution andriol dosage should be used within 24 hours. It is necessary to destroy unused solution.
Before application on / in the solution must be checked for transparency, the presence of particles precipitate, discoloration and leakage in all cases where this leads to the solution and the packaging material. Do not use the drug if it is cloudy, contains particles, sediment, if it has changed color or traces of sagging.
USE IN CERTAIN PATIENTS GROUP
Currently no data that would indicate the need for dose adjustment in elderly patients and in patients with impaired renal function. Since there is evidence of an increase in half-life of octreotide in patients with cirrhosis of the liver, it is recommended maintenance dose adjustment in patients with impaired hepatic function. Experience with octreotide in children is limited.
ADVERSE EFFECTS Local reactions: possible pain, itching, or burning, redness or swelling at the s / c injection (usually disappear within 15 minutes).
Intensity of local reactions may be reduced by using the solution to room temperature, or introducing a smaller volume of a more concentrated solution.
On the part of the digestive tract: anorexia, nausea, vomiting, abdominal cramping, bloating, excessive gas, loose stools, diarrhea, steatorrhea. While the selection of fat in the feces can be increased, to date there is no evidence that long-term treatment with octreotide may lead to nutritional deficiency due to malabsorption (malabsorption). In rare cases, it can be observed phenomena resemble acute intestinal. Obstruction: progressive abdominal distension, severe epigastric pain, tension of the abdominal wall. Long-term use of octreotide may result in the formation of gallstones. The frequency of side effects from the gastrointestinal tract can be reduced by increasing the intervals between meals and administration of octreotide.
On the part of the pancreas: reports deca durabolin cycle of rare cases of acute pancreatitis that developed in the first hours or days of use of octreotide. With andriol dosage prolonged use there have been cases of pancreatitis associated with cholelithiasis. steroid purchase online steroid suppliers uk buy steroids online