Timolol is a non-selective blocker of beta-adrenergic receptors. It has no intrinsic sympathomimetic and membrane stabilizing activity.
When applied topically as eye drops reduce both normal and elevated intraocular pressure by decreasing the formation of intraocular fluid. It has no influence on pupil size and accommodation. The andriol side effectsaction of the drug is 20 minutes after instillation into conjunctival cavity. The maximum decrease in intraocular pressure deca durabolin price occurs within 1-2 hours and lasts for 24 hours.
When applied topically timolol rapidly penetrates the cornea. After instillation of the eye drops of timolol maximum concentration achieved within 1-2 hours of aqueous humor in the anterior chamber. The small amount reaches the systemic circulation by absorption through the vessels of the conjunctiva, nasal mucosa and lacrimal tract. Excretion of metabolites of timolol is carried out mainly by the kidneys. In infants and young children the maximum concentration significantly higher than that in adult plasma.
- increased intraocular pressure (ocular hypertension);
- open-angle glaucoma;
- secondary glaucoma;
- as an additional means for reducing the intraocular pressure in angle-closure glaucoma (in combination with miotikami);
- congenital glaucoma (with failure of other therapeutic measures).
Individual hypersensitivity to the drug, as well as patients with a history of the following diseases are present:
- asthma or other severe chronic obstructive airway disease; sinus bradycardia;
- atrioventricular block II or III degree;
- congestive heart failure;
- severe chronic heart failure (III – IV functional class);
- cardiogenic shock;
- allergic reaction with generalized skin rash;
- atrophic rhinitis;
- degenerative diseases of the cornea;
- the neonatal period
In patients with pulmonary disease, emphysema, severe cerebrovascular insufficiency, congestive heart failure (functional class 1-11), sinoatrial blockade, hypotension, diabetes, hypoglycemia, thyrotoxicosis, myasthenia, Raynaud’s syndrome, pheochromocytoma, and while the appointment of other beta-blockers, children’s age.
Pregnancy and lactation
sufficient experience of use of the drug during pregnancy, lactation and children do not have, however, shown that timolol passes the placental barrier and enters the breast milk. Perhaps the use of the drug Okumed ® for the treatment of children and pregnant women if the expected therapeutic effect is greater than the risk of possible side effects. During the use of the drug should stop breastfeeding.
Side effects: Local reactions: irritation and redness of the conjunctiva, eyelid skin, burning and itchy eyes, watery eyes, or a decrease in lacrimation, photophobia, edema of the corneal epithelium, superficial punctate keratopathy, gipostezii cornea, diplopia, ptosis, dry eyes, a short break in visual acuity, blepharitis , conjunctivitis, keratitis. During the antiglaukomatoznyh operations may develop detachment of the choroid in the postoperative period. Systemic reactions: Cardio-vascular system: congestive heart failure, bradycardia, bradyarrhythmia, decreased blood pressure, collapse, deca andriol side effects durabolin price atrioventricular block, heart failure, transient ischemic attacks. From the respiratory system: dyspnea, bronchospasm, pulmonary insufficiency. On the part of the central nervous system: headache, dizziness, myasthenia gravis, depression, paresthesia, drowsiness, hallucinations, tinnitus, slowing of psychomotor reactions. On the part of the gastrointestinal tract: nausea, vomiting , diarrhea. Allergic reactions: urticaria, eczema.Rhinitis, nasal bleeding, chest pain, decreased potency, alopecia. In case of side effects, discontinue using the product and how to contact your doctor as soon as possible.
is possible to develop obscherezorbtivnyh effects typical of beta-blockers: dizziness, headache, arrhythmia, bradycardia, bronchospasm, nausea, vomiting. Treatment: rinse immediately with water or 0.9% sodium chloride solution, symptomatic therapy.
Interaction with other medicinal products
Co-administration of the drug eye drops containing epinephrine may cause pupil dilation.
The specific effect of the drug – reducing the intraocular pressure increases with simultaneous use of eye drops containing epinephrine and pilocarpine; instilled into the eyes of two beta-blocker should not be.
Lowering blood pressure and slowing heart rate may increase in the combined use of the drug with blockers of slow calcium channels, reserpine and other beta-blockers.
Concomitant use with insulin or oral antidiabetic agents may cause hypoglycemia.
You can not simultaneous use with antipsychotic drugs (neuroleptics) and anxiolytic drugs (tranquilizers).
During treatment is not recommended to take ethanol (perhaps a sharp decrease in blood pressure).
timolol increases the effects of peripheral muscle relaxants, so requires removal of the drug 48 hours before planned surgery with general anesthesia.
best place to buy anabolic steroids online
is necessary to visit a doctor to measure intraocular pressure and corneal examination.
If the patient wears soft contact lenses, he should not use eye drops andriol side effects and 0.5% as a preservative can be sorbed soft contact lens material, and have adverse effects on the eye tissue.
it should remove hard contact lenses prior to instillation of the drug and to wear them again only after 15 minutes.
Immediately after instillation of the drug may reduce visual acuity and slower mental deca durabolin price reactions, which may reduce the ability to actively participate in road traffic, maintenance of machines or to perform work without support. To an even greater extent this is the case, while the use of the drug with alcohol.
When transferring patients to treatment with timolol may need refractive error correction after effects caused by previously used miotikami. In the case of the upcoming surgery with general anesthesia, it is necessary to cancel the drug for 48 hours. buy legal anabolic steroids online
best place to buy anabolic steroids online